Mapping and modelling the impact of mass drug adminstration on filariasis prevalence in Myanmar

作     者：Ni Ni Aye Zaw Lin Khin Nan Lon Nay Yi Yi Linn Thet Wai Nwe Khin Mon Mon Kapa Ramaiah Hannah Betts Louise A.Kelly-Hope Aye Ni Ni;Lin Zaw;Lon Khin Nan;Linn Nay Yi Yi;Nwe Thet Wai;Mon Khin Mon;Ramaiah Kapa;Betts Hannah;Kelly-Hope Louise A.

作者机构：Ministry of Health and SportsDepartment of Public HealthNay Pyi TawMyanmar Tagore NagarPondicherryIndia Department of ParasitologyCentre for Neglected Tropical DiseasesLiverpool School of Tropical MedicineLiverpoolUK 

出 版 物：《Infectious Diseases of Poverty》 (贫困所致传染病（英文）)

年 卷 期：2018年第7卷第1期

页      面：541-551页

核心收录：

学科分类：1004[医学-公共卫生与预防医学(可授医学、理学学位)] 1002[医学-临床医学] 1001[医学-基础医学(可授医学、理学学位)] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

基　　金：The LF programme activities were supported by the Ministry of Health and Sports,and funds from the Centre for Neglected Tropical Diseases(CNTD) Liverpool,UK through a grant from the Department for International Development(DFID)and GlaxoSmithKline(GSK)for the elimination of lymphatic filariasis 

主　　题：Lymphatic filariasis Elephantiasis Wuchereria bancrofti Neglected tropical diseases Mass drug administration Transmission assessment surveys Surveillance Myanmar 

摘      要：Background:Lymphatic filariasis(LF)is endemic in Myanmar and targeted for *** highlight the National Programme to Eliminate Lymphatic Filariasis(NPELF)progress between 2000 and 2014,this paper describes the geographical distribution of LF,the scale-up and impact of mass drug administration(MDA)implementation,and the first evidence of the decline in transmission in five ***:The LF distribution was determined by mapping historical and baseline prevalence data collected by *** on the MDA implementation,reported coverage rates and sentinel site surveillance were summarized.A statistical model was developed from the available prevalence data to predict prevalence at township level by year of *** assessment survey(TAS)methods,measuring antigenemia(Ag)prevalence in children,were used to determine whether prevalence was below a level where recrudescence is unlikely to ***:The highest baseline LF prevalence was found in the Central Valley *** MDA implementation activities scaled up to cover 45 districts,representing the majority of the endemic population,with drug coverage rates ranging from 60.0%to 98.5%.Challenges related to drug supply and local conflict were reported,and interrupted MDA in some ***,significant reductions in LF prevalence were found,especially after the first 2 to 3 rounds of MDA,which was supported by the corresponding *** TAS activities in five districts found only two Ag positive children,resulting in all districts passing the critical ***:Overall,the Myanmar NPELF has made positive steps forward in the elimination of LF despite several challenges,however,it needs to maintain momentum,drawing on international stakeholder support,to aim towards the national and global goals of elimination.