High prevalence of epilepsy in onchocerciasis endemic health areas in Democratic Republic of the Congo

作     者：Evy Lenaerts Michel Mandro Deby Mukendi Patrick Suykerbuyk Housseini Dolo Deogratias Wonya’Rossi Françoise Ngave Chellafe Ensoy-Musoro Anne Laudisoit An Hotterbeekx Robert Colebunders 

作者机构：Global Health InstituteUniversity of AntwerpAntwerpBelgium Provincial Health Division of IturiMinistry of HealthBuniaDemocratic Republic of Congo Centre Neuro Psycho PathologiqueUniversitede Kinshasa(CNPP-UNIKIN)KinshasaDemocratic Republic of Congo International Center of Excellence in ResearchFaculty of Medicine and OdontostomatologyBamakoMali Neglected Tropical Diseases Control programMinistry of HealthBuniaDemocratic Republic of the Congo Centre de Recherche en Maladies TropicalesHopital General de Reference de RethyRethyDemocratic Republic of Congo Interuniversity Institute for Biostatistics and statistical BioinformaticsUniversity of HasseltHasseltBelgium EcoHealth AllianceNew YorkUSA Global Health InstituteFaculty of Medicine and Health SciencesGouverneur Kinsbergen CentrumDoornstraat 3312610 WilrijkBelgium 

出 版 物：《Infectious Diseases of Poverty》 (贫困所致传染病（英文）)

年 卷 期：2018年第7卷第1期

页      面：663-676页

核心收录：

学科分类：1004[医学-公共卫生与预防医学(可授医学、理学学位)] 1002[医学-临床医学] 1001[医学-基础医学(可授医学、理学学位)] 10[医学] 

基　　金：CR received funding from the European Research Council(grant No.ERC 671055) 

主　　题：Onchocerciasis epilepsy Prevalence Democratic Republic of Congo 

摘      要：Background:A high prevalence of epilepsy has been observed in many onchocerciasis endemic *** study is to estimate the prevalence of active epilepsy and exposure to Onchocerca volvulus infection in a rural population in Ituri province,Democratic Republic of ***:In August 2016,a community-based cross-sectional study was conducted in an onchocerciasis endemic area in the rural health zone of Logo,Ituri *** within two neighbouring health areas were randomly *** identify persons with epilepsy,a three-stage approach was *** the first stage,all individuals of the selected households were screened for epilepsy by non-medical field workers using a validated 5-item *** the second and third stage,suspected cases of epilepsy were examined by non-specialist medical doctors,and by a neurologist,respectively.A case of epilepsy was defined according to the 2014 International League Against Epilepsy(ILAE)*** to *** was assessed by testing for IgG4 antibodies to an *** antigen(OV16 Rapid Test,)in individuals aged 3 years and ***:Out of 1389 participants included in the survey,64 were considered to have active epilepsy(prevalence 4.6%)(95%confidence interval[CI]:3.6-5.8).The highest age-specific epilepsy prevalence estimate was observed in those aged 20 to 29 years(8.2%).Median age of epilepsy onset was 10 years,with a peak incidence of epilepsy in the 10 to 15 year-old age ***16 test results were available for 912 participants,of whom 30.5%(95%CI,27.6-33.6)tested *** prevalence of OV16 positivity in a village ranged from 8.6 to 68.0%.After adjusting for age,gender and ivermectin use,a significant association between exposure to onchocerciasis and epilepsy was observed(adjusted odds ratio=3.19,95%CI:1.63-5.64)(P0.001).Conclusions:A high prevalence of epilepsy and a significant association between epilepsy and exposure to *** were observed in the population in Ituri