Concomitant visceral and localized cutaneous leishmaniasis in two Moroccan infants

作     者：Tarik Mouttaki Hasnaa Maksouri Jilali El Mabrouki Gema Merino-Espinosa Hassan Fellah Mohamed Itri Joaquina Martin-Sanchez Maha Soussi-Abdallaoui Soumiya Chiheb Myriam Riyad 

作者机构：Centre of Doctoral Studies on Health Sciences(CED.des Sciences de la Sante)Doctoral School of ImmunopathologyFaculty of Medicine and PharmacyHassan II University of CasablancaCasablancaMorocco Research Team on Immunopathology of Infectious and Systemic DiseasesFaculty of Medicine and PharmacyHassan II University of CasablancaCasablancaMorocco Laboratory of Parasitology and MycologyUniversity Hospital Ibn Rochd of CasablancaCasablancaMorocco Department of ParasitologyFaculty of PharmacyUniversity of GranadaGranadaSpain Children’s HospitalUniversity Hospital Ibn Rochd of CasablancaCasablancaMorocco Laboratory of ParasitologyFaculty of Medicine and PharmacyHassan II University of Casablanca19 rue Tarik Ibn ZiadBP.9154 CasablancaMorocco Department of DermatologyUniversity Hospital Ibn Rochd of CasablancaCasablancaMorocco 

出 版 物：《Infectious Diseases of Poverty》 (贫困所致传染病（英文）)

年 卷 期：2018年第7卷第1期

页      面：330-334页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

主　　题：Visceral leishmaniasis Cutaneous leishmaniasis Leishmania infantum Leishmania tropica Infants Morocco 

摘      要：Background:Leishmaniases are vector-borne diseases caused by the protozoa of the Leishmania *** clinical spectrum of these diseases extends from benign dermal lesions to visceral *** the Mediterranean region,zoonotic visceral leishmaniasis(ZVL)is caused by *** untreated within two years,the disease usually leads to *** Morocco,ZVL is endemic in the north,with a hundred cases notified each year,mostly in children aged below five ***,we report on two clinical observations in infants presenting unusual concomitant VL and cutaneous leishmaniasis(CL)in *** presentation:In this case study,we report on two infants aged nine and 12 months *** both have a history of febrile splenomegaly,anemia,and pallor of mucous *** leishmaniasis was confirmed by parasitological diagnosis(positive bone marrow smear and screening of *** antibodies).However,the clinical examination also showed cutaneous lesions that suggested the presence of *** was reinforced by the patients having a history of living or traveling to endemic ***,direct examination,culture,and PCR-RFLP(ITS1-Hae 3)were carried out on the patients’dermal *** one of the infants,CL was associated with ***,while in the other it was associated with *** infants were treated as according to the recommendations of the Ministry of *** patients were cured in two months;defervescence,reduction of splenomegaly,and healing of cutaneous lesions were all ***:These singular patients illustrate the clinical polymorphism of CL and the necessity of updating the differential diagnosis of leukemia-like syndromes,including VL,in children living in or travelling to known endemic *** observations suggest a change in the Mediterranean VL phenotype that may be associated with CL.