High prevalence of epilepsy in two rural onchocerciasis endemic villages in the Mahenge area,Tanzania,after 20 years of community directed treatment with ivermectin
作者机构：National Institute for Medical ResearchTanga Research CentreTangaTanzania Global Health InstituteUniversity of AntwerpAntwerpBelgium Muhimbili National HospitalDar es SalaamTanzania Enhance Tanzania FoundationDar es SalaamTanzania Muhimbili University of Health and allied SciencesDar es SalaamTanzania University of Texas Medical BranchGalvestonTXUSA
出 版 物：《Infectious Diseases of Poverty》 (贫困所致传染病（英文）)
年 卷 期：2018年第7卷第1期
页 面：622-634页
核心收录：
基 金：CR received funding from the European Research Council(grant ERC 671055)
主 题：Epilepsy Onchocerciasis Mahenge Tanzania
摘 要：Background:Epilepsy is a neurological disorder with a multitude of underlying causes,which may include infection with Onchocerca volvulus,the parasitic worm that causes human onchocerciasis.A survey carried out in 1989 revealed a high prevalence of epilepsy(1.02%overall,ranging from 0.51 to 3.71%in ten villages)in the Mahenge area of Ulanga district,an onchocerciasis endemic region in south eastern *** study aimed to determine the prevalence and incidence of epilepsy following 20 years of onchocerciasis control through annual community directed treatment with ivermectin(CDTI).Methods:The study was conducted in January 2017 in two suburban and two rural villages in the Mahenge ***-todoor household visits were carried out by trained community health workers and data assistants to screen for persons suspected of having epilepsy,using a standardised *** with suspected epilepsy were then interviewed and examined by a neurologist for case *** associated epilepsy was defined as epilepsy without an obvious cause,with an onset of seizures between the ages of 3-18 years in previously healthy *** each village,fifty males aged≥20 years were tested for onchocerciasis antibodies using an OV16 rapid test and were examined for presence of onchocerciasis *** aged 6-10 years were also tested using OV16 ***:5117 individuals(median age 18.5 years,53.2%female)from 1168 households were screened.244(4.8%)were suspected of having epilepsy and invited for neurological *** of epilepsy was 2.5%,with the rural villages having the highest rate(3.5%vs 1.5%),P*** incidence of epilepsy was 111 cases(95%CI:73-161)per 100000 person-years,while that of onchocerciasis associated epilepsy was 131(95%CI:70-223).Prevalence of OV16 antibodies in adult males and among children 6-10 years old was higher in rural villages than in suburban villages(76.5%vs 50.6,and 42.6%vs 4.7%respectively),(P
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