Genetic studies of schizophrenia:an update

作     者：Jingchun Chen Fei Cao Lanfen Liu Lina Wang Xiangning Chen 

作者机构：Virginia Institute for Psychiatric and Behavioral GeneticsVirginia Commonwealth University Department of NeurologyUnion HospitalTongji Medical CollegeHuazhong University of Science and Technology Department of PsychiatryShandong Mental Health Center 

出 版 物：《Neuroscience Bulletin》 (神经科学通报（英文版）)

年 卷 期：2015年第31卷第1期

页      面：87-98页

核心收录：

学科分类：1002[医学-临床医学] 100205[医学-精神病与精神卫生学] 10[医学] 

基　　金：supported by the National Institutes of Health USA (MH101054) 

主　　题：schizophrenia genome wide association study copy number variant de novo mutation sequencing genetics 

摘      要：Schizophrenia（SCZ） is a complex and heterogeneous mental disorder that affects about 1% of global population. In recent years,considerable progress has been made in genetic studies of SCZ. A number of common variants with small effects and rare variants with relatively larger effects have been identifi ed. These variants include risk loci identifi ed by genome-wide association studies,rare copy-number variants identifi ed by comparative genomic analyses,and de novo mutations identified by high-throughput DNA sequencing. Collectively,they contribute to the heterogeneity of the disease. In this review,we update recent discoveries in the fi eld of SCZ genetics,and outline the perspectives of future directions.