Survivin mRNA expression in urine as a biomarker for patients with transitional cell carcinoma of bladder

作     者：HOU Jian-quan HE Jun WEN Duan-gai CHEN Zi-xing ZENG Jian 

作者机构：Department of Urology Jiangsu Institute of Hematology First Affiliated Hospital of Soochow University Suzhou 215006 China 

出 版 物：《Chinese Medical Journal》 (中华医学杂志（英文版）)

年 卷 期：2006年第119卷第13期

页      面：1118-1120页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：This work was supported by grants from the Talent Man Foundation of Jiangsu Province (No.RC2003094) as well as the Science Foundation of Jiangsu Province (No.H200517) 

主　　题：transitional cell carcinoma of bladder survivin real time-polymerase chain reaction 

摘      要：Transitional cell carcinoma （TCC） of bladder is the most common malignant tumor in uropoiesis system. Up to date, there is still lack of an ideal marker for the diagnosis of TCC except CT and MRI imaging and cystoscopy. Cystoscopy is an invasive examination, which increases the possibility of urinary tract infection. Urine cytology has low sensitivity （21%--40%） in diagnosis of bladder cancer, especially for those with medium or high differentiation. The specificity is often affected by factors such as specimen collection, urinary tract infection, etc. Detecting the expression of survivin mRNA in urine by real time-PCR is simple in specimen collection and is sensitive and relatively specific, which provides a simple and noninvasive diagnostic method for TCC. Moreover it allows comparing the gene expression levels at different stages and grades of TCC, which can help define malignancy degree of TCC.