Impact of meteorological factors on the incidence of childhood hand,foot,and mouth disease(HFMD)analyzed by DLNMs-based time series approach

作     者：Hongchao Qi Yue Chen Dongli Xu Hualin Su Longwen Zhan Zhiyin Xu Ying Huang Qianshan He Yi Hu Henry Lynn Zhijie Zhang 

作者机构：Department of Epidemiology and BiostatisticsSchool of Public HealthFudan UniversityShanghai 20002China Key Laboratory of Public Health SafetyMinistry of EducationShanghai 200032China Collaborative Innovation Center of Social Risks Governance in HealthSchool of Public HealthFudan UniversityShanghai 200032China School of EpidemiologyPubic Health and Preventive MedicineFaculty of MedicineUniversity of Ottawa451 Smyth RdOttawaON 10610Canada Minghang District Center for Disease Control and PreventionShanghai 201101China Shanghai Meteorological ServiceShanghai 201499China Shanghai Key Laboratory of Meteorology and HealthShanghai 201499China 

出 版 物：《Infectious Diseases of Poverty》 (贫困所致传染病（英文）)

年 卷 期：2018年第7卷第1期

页      面：77-86页

核心收录：

学科分类：1002[医学-临床医学] 100202[医学-儿科学] 10[医学] 

基　　金：This research was supported by the National Natural Science Foundation of China(grant number 81673239) the National Science Fund for Distinguished Young Scholars(grant number 81325017) Chang Jiang Scholars Program(grant number T2014089) the Fourth Round of Three-Year Public Health Action Plan of Shanghai,China(grant numbers 15GWZK0202,15GWZK0101) 

主　　题：Hand foot and mouth disease Meteorological factor Distributed lag non-linear model 

摘      要：Background:Hand,foot,and mouth disease(HFMD)has become an emerging infectious disease in China in the last *** has been evidence that meteorological factors can influence the HFMD incidence,and understanding the mechanisms can help prevent and control ***:HFMD incidence data and meteorological data in Minhang District,Shanghai were obtained for the period between 2009 and *** lag non-linear models(DLNMs)were utilized to investigate the impact of meteorological factors on HFMD incidence after adjusting for potential confounders of long time trend,weekdays and ***:There was a non-linear relationship between temperature and HFMD incidence,the RR of 5th percentile compared to the median is 0.836(95%CI:0.671-1.042)and the RR of 95th percentile is 2.225(95%CI:1.774-2.792),and the effect of temperature varied across age *** incidence increased with increasing average relative humidity(%)(RR=1.009,95%CI:1.005-1.015)and wind speed(m/s)(RR=1.197,95%CI:1.118-1.282),and with decreasing daily rainfall(mm)(RR=0.992,95%CI:0.987-0.997)and sunshine hours(h)(RR=0.966,95%CI:0.951-0.980).Conclusions:There were significant relationships between meteorological factors and childhood HFMD incidence in Minhang District,*** information can help local health agencies develop strategies for the control and prevention of HFMD under specific climatic conditions.