Catalytic Asymmetric Cross-Dehydrogenative Coupling of 2H-Chromenes and Aldehydes

作     者：Xinhui Pan Xigong Liu Shutao Sun Zhilin Meng Lei Liu 

作者机构：School of Pharmaceutical SciencesShandong UniversityJinanShandong 250012China School of Chemistry and Chemical EngineeringShandong UniversityJinanShandong 250100China Key Laboratory of Xinjiang Phytomedicine Resource and UtilizationMinistry of EducationSchool of Pharmaceutical SciencesShihezi UniversityShiheziXinjiang 832002China 

出 版 物：《Chinese Journal of Chemistry》 (中国化学（英文版）)

年 卷 期：2018年第36卷第12期

页      面：1187-1190页

核心收录：

学科分类：07[理学] 0703[理学-化学] 

基　　金：the National Natural Science Foundation of China (Nos.21722204,21472112) the Fok Ying Tung Education Foundation (No.151035)for support 

主　　题：2H‐chromene aldehyde asymmetric catalysis C—H functionalization oxidation synthetic method 

摘      要：The first catalytic asymmetric cross‐dehydrogenative coupling of 2H‐chromenes with aldehydes using o‐chloranil (3,4,5,6‐tetrachloro‐1,2‐ benzoquinone) as an oxidant has been described. The organocatalytic process is tolerated with a broad range of structurally and electronically varied 2H‐chromenes and aldehydes with good yield and high enantiocontrol. The first catalytic asymmetric cross‐dehydrogenative coupling of 2H‐chromenes with aldehydes using o‐chloranil as an oxidant has been described. The organocatalytic process is tolerated with a broad range of structurally and electronically varied 2H‐chromenes and aldehydes with good yield and high enantiocontrol. [ABSTRACT FROM AUTHOR]