ⅡB～ⅣA期宫颈癌患者接受放疗和顺铂化疗同时应用重组人促红细胞生成素作辅助治疗:西南肿瘤组研究

作     者：Lavey R.S. Greer B.E. 李宁 

出 版 物：《世界核心医学期刊文摘（妇产科学分册）》 (Core Journal in Obstetrics/Gynecology)

年 卷 期：2005年第1卷第2期

页      面：53-54页

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

主　　题：顺铂化疗 腔内放疗 全盆腔 晚期宫颈癌 深静脉血栓形成 口服铁剂 rHuEPO 率比 

摘      要：The survival of cervix cancer patien ts is associated with their hemoglobin(Hgb)level during *** Southwest Oncology Group(SWOG)conducted a phase IItrial to determine whether recombin ant human erythropoi-etin(rHuEPO)safely corrects anemia during chemo radio-therapy for cervix *** had stage IIB -IVA cervix cancer and a Hgb between 8.0an d 12.5g /*** patients received rHuEPO thrice weekly and oral iron starting 10-15days before their 5-week course of whole pelvic irradiation and weekly cispl atin followed by intra-cavitary *** -thr ee patients from 26in-stitutions received the protocol tr *** mean Hgb was 10.4±1.3g /dl on the first day of r HuEPO admin-istration(baseline)-,11.0±1.6g /dl on the first day of chemoradiotherapy,11.6±1.9g /d l at the midpoint of chemoradiotherapy,and 11.8±2.2g /dl at the end of *** target Hgb l evel of 12.5g /dl was achieved in 40%of patients(95%CI 26-56%)by the midpoint of *** in Hgb was as-sociated with baseline serum iron(P =0.008)and trans-ferrin saturation(P =0.05)levels,but not with baseline Hgb or serum ferritin,or patient *** patients de-veloped deep vein *** -y ear progression -free survival(PFS)was 43%and overall survival(OS)was 51%.Survival was significantly associated with Hgb level at the end of chemoradiotherap y,but not with the baseline Hgb *** and iron g radually increased Hgb levels in anemic women with local advanced cervix cancer during chemoradiotherapy.T here was a higher than expected incidence of deep vein thro *** progres-sion -free and overall survival rate s were lower than re-ported for women with normal Hgb levels.