LIMITATIONS OF CANCER MARGIN DELINEATION BY MEANS OF AUTOFLUORESCENCE IMAGING UNDER CONDITIONS OF LASER SURGERY

作     者：ALEXANDRE DOUPLIK AZHAR ZAM RALPH HOHENSTEIN ANGELOS KALITZEOS EMEKA NKENKE FLORIAN STELZLE 

作者机构：SAOT—Erlangen Graduate School in Advanced Optical Technologies Friedrich-Alexander University ErlangenNurembergGermany Department of Photonic Technologies Friedrich-Alexander University ErlangenNurembergGermany Department of Oral and Maxillofacial Surgery Friedrich-Alexander University ErlangenNurembergGermany 

出 版 物：《Journal of Innovative Optical Health Sciences》 (创新光学健康科学杂志（英文）)

年 卷 期：2010年第3卷第1期

页      面：45-51页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：the Erlangen Graduate School in Advanced Optical Technologies(SAOT)by the German National Science Foundation(DFG)in the framework of the excellence initiative and Bavarian Laser Centre(BLZ)for support of this study 

主　　题：Cancer margin delineation surgical guidance surgical navigation autofluorescence imaging laser surgery laser ablation 

摘      要：Limitations of cancer margin delineation and surgical guidance by means of autofluorescence imaging under conditions of laser ablation were investigated and preliminary results are ***^(TM)(Novadaq Technologies Inc.,Canada)was used to capture digital images and Er:YAG laser(2.94μm,Glissando,WaveLight^(TM),Germany)was exploited to cause laser ablation on both normal and cancer sites of the *** was shown that changes of the autofluorescence image after ablation extend beyond the actual sizes of the ablation *** tumor tissue after the laser ablation starts to emit fluorescent light within the green wavelength band(490-550nm)similar to normal tissue stating that the current technology of in-process tissue classification ***,when the autofluorescence was collected in the red range(600-750nm),then the abnormal/normal contrast was reduced,but still present even after the laser *** present study highlights the importance of finding a proper technology for surgical navigation of cancer removal under conditions of high power effects in biological tissues.