A New Phosphine-Amine-Oxazoline Ligand for Ru-Catalyzed Asymmetric Hydrogenation of N-Phosphinylimines

作     者：Xiaochen Ma Lin Qiao Guixia Liu Zheng Huang 

作者机构：State Key laboratory of Organometallic ChemistryCenter for Excellence in Molecular SynthesisShanghai Institute of Organic ChemistryUniversity of Chinese Academy of SciencesChinese Academy of Sciences345 Lingling RdShanghai 200032China 

出 版 物：《Chinese Journal of Chemistry》 (中国化学（英文版）)

年 卷 期：2018年第36卷第12期

页      面：1151-1155页

核心收录：

学科分类：07[理学] 0703[理学-化学] 

基　　金：The National Key R&D Program of China (Nos.2015CB856600, 2016YFA0202900) the National Natural Science Foundation of China (Nos.21422209,21432011,21421091,21572255) Chinese Academy of Sciences (No.XDB20000000) 

主　　题：amines chiral ligand hydrogenation imines ruthenium 

摘      要：A series of chiral phosphine‐amine‐oxazoline (PAO) ligands with an NH moiety were synthesized and applied to the ruthenium‐catalyzed asymmetric hydrogenation of N ‐phosphinylimines. The ligand bearing phenyl groups at the phosphorus moiety and isopropyl at the oxazoline moiety exhibits good activity and excellent enantioselectivity (up to 99% ee ). This catalytic system provides an efficient and mild approach to access enantioriched amines.