Multidisciplinary management of recurrent and metastatic hepatocellular carcinoma after resection: an international expert consensus

作     者：Tianfu Wen Chen Jin Antonio Facciorusso Matteo Donadon Ho-Seong Han Yilei Mao Chaoliu Dai Shuqun Cheng Bixiang Zhang Baogang Peng Shunda Du Changjun Jia Feng Xu Jie Shi Juxian Sun Peng Zhu Satoshi Nara JMichael Millis Qiu Li Weixia Chen Wusheng Lu Hong Tang Lvnan Yan Yong Zeng Bo Li Jiayin Yang Wentao Wang Hong Wu Mingqing Xu Zheyu Chen Changli Lu Chuan Li Wei Peng Xiaoyun Zhang 

作者机构：Department of Liver Surgery and Liver Transplantation CenterWest China HospitalSichuan UniversityChengdu 610041China Department of Medical and Surgical SciencesUniversity of FoggiaFoggiaItaly Department of Hepatobiliary&General SurgeryHumanitas UniversityHumanitas Clinical and Research CenterMilanItaly Seoul National University Bundang HospitalSeoul National University College of MedicineSeoulKorea Department of Liver SurgeryPeking Union Medical College HospitalChinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100730China Department of Hepatobiliary and Splenic SurgeryShengjing HospitalChina Medical UniversityShenyang 110000China Department of Hepatic Surgery VIEastern Hepatobiliary Surgery HospitalThe Second Military Medical UniversityShanghai 200433China Hepatic Surgery CenterTongji HospitalHuazhong University of Science and TechnologyWuhan 430030China Department of Liver Surgerythe First Affiliated Hospital of Sun Yat-sen UniversityGuangzhou 510080China Hepatobiliary and Pancreatic Surgery DivisionNational Cancer Center HospitalTokyoJapan Department of SurgeryUniversity of ChicagoChicagoILUSA MDT of West China Hospital Department of Medical OncologyCancer CenterState Key Laboratory of BiotherapyWest China HospitalSichuan UniversityChengdu 610041China Department of RadiologyWest China HospitalSichuan UniversityChengdu 610041China Center of Infectious DiseasesWest China HospitalSichuan UniversityChengdu 610041China 

出 版 物：《Hepatobiliary Surgery and Nutrition》 (肝胆外科与营养（英文）)

年 卷 期：2018年第7卷第5期

页      面：353-371页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：supported by Chinese Society of Liver Cancer,Chinese Medical Doctor Association and Surgical Technology Innovation and Promotion Association,NAHIEM,China This work was in part supported by grants from the State Key Scientific and Technological Research Programs(2017ZX10203207-003-0020) the Scientific and Technological Support Project of Sichuan Province(2018SZ0204,2016SZ0025 and 2015SZ0049) 

主　　题：Recurrent hepatocellular carcinoma (RHCC) multidisciplinary management consensus 

摘      要：Hepatocellular carcinoma (HCC) is the sixth-most common cancer and the third leading cause of cancer-related death in the world. However, 40–70% patients eventually suffer from postoperative recurrence within 5 years. HCC recurrence after surgery severely affects prognosis of the patients. Nevertheless, there is an opportunity to improve patients prognosis if doctors and researchers can recognize the importance of a standardized perioperative management and study it in clinical and pre-clinical settings. Hence, based on our own experience and published studies from other researchers, we develop this consensus regarding multidisciplinary management of locally recurrent and metastatic hepatocellular carcinoma after resection. This consensus consists of the entire course of recurrent hepatocellular carcinoma (RHCC) management, including prediction of recurrence, prevention, diagnosis, treatment and surveillance of RHCC. Consensus recommendations are presented with grades of evidences (Ia, Ib, IIa, IIb, III and IV), and strength ofrecommendations (A, B, C, D and E). We also develop a decision-making path for RHCC treatment, which can intuitively demonstrate the management for RHCC. It is hoped that we may make some effort to standardize the management of RHCC and ultimately understand how to improve outcomes.