The Effects of DPPH on Cochlear Microcirculation

作     者：孔维佳 陈敏 KONG Weijia CHEN Min Department of Otolaryngology, Xiehe Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022

作者机构：Department of OtolaryngologyXiehe HospitalTongji Medical CollegeHuazhong University of Science and Technology Wuhan 430022 

出 版 物：《Journal of Huazhong University of Science and Technology(Medical Sciences)》 (华中科技大学学报（医学英德文版）)

年 卷 期：2003年第23卷第2期

页      面：198-200页

核心收录：

学科分类：1002[医学-临床医学] 100213[医学-耳鼻咽喉科学] 10[医学] 

基　　金：This project was supported by grants of the Research Foundation for Outstanding Scientists(Serial No.1995-144) the State Outstanding Young Scences Foundation(39925035)and Foundation for University Key Teachers by the Ministry of Education(2001) 

主　　题：DPPH laser Dopper flowmeter cochlear blood flow 

摘      要：To investigate the effects of the free radical, 1, l-Diphenyl-2-picylhydrazyl, on cochlear blood flow, 20 guinea pigs were divided into 3 groups at random, 6 for control group, 6 for 1 mmol/ L group and 8 for 0. 1 mmol/L group. 2 μl vehicle or drugs were dropped into round window membrane (RWM). Cochlear microcirculation was monitored by laser Doppler flowmeter (LDF), and mean arterial blood flow (MABP), which was transferred by pressure conductor sensor and preamplifier, was simultaneously recorded on the computer. Our results showed that MABP was stable throughout the experiment. Cochlear blood flow (CBF) increased by 10. 32 % (P0. 05) in 1 mmol/L group, and decreased by 4. 89 % in 0. 1 mmol/L group (P0. 05). In control group cochlear microcirculation showed no significant changes. It is concluded that DPPH exerted effects on cochlear microcirculation.