Differential Effects of Butyric Acid on Mouse Skin Tumorigenesis

作     者：KRISHNAP·GUPTA N·K·MEHROTRA 

作者机构：EnvironmentalCarcinogenesisLaboratoryIndustrialToxicologyResearchCentre EnvironmentalCarcinogenesisL 

出 版 物：《Biomedical and Environmental Sciences》 (生物医学与环境科学（英文版）)

年 卷 期：1997年第10卷第4期

页      面：436-441页

核心收录：

学科分类：1007[医学-药学(可授医学、理学学位)] 1006[医学-中西医结合] 0830[工学-环境科学与工程（可授工学、理学、农学学位）] 1004[医学-公共卫生与预防医学(可授医学、理学学位)] 100706[医学-药理学] 1002[医学-临床医学] 1001[医学-基础医学(可授医学、理学学位)] 100214[医学-肿瘤学] 10[医学] 100602[医学-中西医结合临床] 

主　　题：DMBA Differential Effects of Butyric Acid on Mouse Skin Tumorigenesis 

摘      要：We studied the effects of butyric acid (BA) on mouse skin tumorigenesis using chronicanimal bioassays. Topical application of BA immediately after each treatment with 12-0-te-t radecanoyl phorbol-13-acetate (TPA) promoter inhi bi ted skint umors. The effect was depe n -dent on the dose of BA applied. BA showed no marked inhibitory effect on either skin tumorinitiation or complete tumorigenesis induced by dimet hyl benzant hracene (DMBA ). Si nce t u -mor promotion reportedly involves epigenetic events whereas tumor initiation or complete tu-morigenesis takes place through genetic pathways, it is Possible that BA exerts its antitumori-genic effects mainly by altering the epigenetic events responsible for tumor promotion. The re-sults of the study could further be used to study the mechanism of action and modification ofantitumorigenic effects of BA in combination with other substances