Regulation of sister chromatid cohesion during the mitotic cell cycle

作     者：ZHENG Ge YU HongTao 

作者机构：Howard Hughes Medical Institute Department of Pharmacology University of Texas Southwestern Medical Center 

出 版 物：《Science China(Life Sciences)》 (中国科学（生命科学英文版）)

年 卷 期：2015年第58卷第11期

页      面：1089-1098页

核心收录：

学科分类：0710[理学-生物学] 07[理学] 071009[理学-细胞生物学] 09[农学] 0901[农学-作物学] 090102[农学-作物遗传育种] 

基　　金：supported by the Welch Foundation(I-1441 to H.Y.) the Clayton Foundation,and Cancer Prevention and Research Institute of Texas(RP110465-P3 and RP120717-P2 to H.Y.) 

主　　题：cell cycle mitosis sister chromatid cohesion cohesin cohesin loading cohesin release DNA replication cohesion estab-lishment 

摘      要：Orderly execution of two critical events during the cell cycle––DNA replication and chromosome segregation––ensures the stable transmission of genetic materials. The cohesin complex physically connects sister chromatids during DNA replication in a process termed sister chromatid cohesion. Timely establishment and dissolution of sister chromatid cohesion is a prerequisite for accurate chromosome segregation, and is tight regulated by the cell cycle machinery and cohesin-associated proteins. In this review, we discuss recent progress in the molecular understanding of sister chromatid cohesion during the mitotic cell cycle.