Synthesis and in vitro biological evaluation of nitric oxide-releasing derivatives of hydroxylcinnamic acids as anti-tumor agents

作     者：Ming-Dong Lu Xiao Zhou Yao-Jun Yu Pi-Hong Li Wei-Jian Sun Cheng-Guang Zhao Zhi-Qiang Zheng Tao You Fei-Hai Wang 

作者机构：Department of General SurgeryThe Second Affiliated HospitalWenzhou Medical College Department of Gynaecology and ObstetricsThe Second Affiliated HospitalWenzhou Medical College School of PharmacyWenzhou Medical College 

出 版 物：《Chinese Chemical Letters》 (中国化学快报（英文版）)

年 卷 期：2013年第24卷第5期

页      面：415-418页

核心收录：

学科分类：1007[医学-药学(可授医学、理学学位)] 0703[理学-化学] 10[医学] 

主　　题：Synthesis Hydroxylcinnamic acids Furoxans NO donor Anti-tumor agents Cytotoxic activities 

摘      要：Novel furoxan-based nitric oxide-releasing derivatives 6a-p of hydroxylcinnamic acids were synthesized by coupling the carboxyl group of hydroxylcinnamic acids with furoxan through various alkylol *** 6a,e-i and m-p displayed more potent anti-tumor activities superior to control 5-fluorouracil（5-FU） in most cancer cells ***,6f could selectively inhibit tumor cells,but not non-tumor cell *** inhibition was attributed to high levels of NO released in cancer cells and potentially synergistic effect of NO donor moieties and the bioactivity of hydroxylcinnamic acids.