Chemical modulation of cell fates： in situ regeneration

作     者：Hua Qin Andong Zhao Xiaobing Fu 

作者机构：Graduate School of Tianjin Medical UniversityTianjin 300070China Cell Biology and Tissue Repair Laboratory Key Laboratory of Wound Repair and Regeneration of PLA the First Hospital Affiliated to the PLA General HospitalBeijing 100048 China College of Life Sciences PLA General Hospital PLA Medical CollegeBeijing 100853 China 

出 版 物：《Science China(Life Sciences)》 (中国科学（生命科学英文版）)

年 卷 期：2018年第61卷第10期

页      面：1137-1150页

核心收录：

学科分类：0831[工学-生物医学工程（可授工学、理学、医学学位）] 08[工学] 0836[工学-生物工程] 

基　　金：supported by the National Natural Science Foundation of China (81721092) the National Key R&D Program of China (2017YFC1103304) 

主　　题：small molecule in situ regeneration adult stem cells somatic cells dedifferentiation transdifferentiation reprogramming 

摘      要：Chemical modulation of cell fates has been widely used to promote tissue and organ regeneration. Small molecules can target the self-renewal, expansion, differentiation, and survival of endogenous stem cells for enhancing their regenerative power or induce dedifferentiation or transdifferentiation of mature cells into proliferative progenitors or specialized cell types needed for regeneration. Here, we discuss current progress and potential using small molecules to promote in vivo regenerative processes by regulating the cell fate. Current studies of small molecules in regeneration will provide insights into developing safe and efficient chemical approaches for in situ tissue repair and regeneration.