New models to study vulvodynia: hyperinnervation and nociceptor sensitization in the female genital tract

作     者：Christine M.Barry Kalyani K.Huilgol Rainer V.Haberberger 

作者机构：Anatomy and Histology College of Medicine and Public Health Flinders University Centre for Neuroscience Flinders University 

出 版 物：《Neural Regeneration Research》 (中国神经再生研究（英文版）)

年 卷 期：2018年第13卷第12期

页      面：2096-2097页

核心收录：

学科分类：1002[医学-临床医学] 100211[医学-妇产科学] 10[医学] 

基　　金：A project described in this work regarding innervation changes in the murine vagina in response to inflammation was supported by a grant from the Centre for Neuroscience Flinders University Australia 

主　　题：New models to study vulvodynia hyperinnervation and nociceptor sensitization in the female genital tract CFA 

摘      要：Vulvodynia is a prevalent form of chronic pain, most com- monly affecting the vaginal vestibule （vestibulodynia） （Pukall et al., 2016）. Women with vulvodynia describe intense pain in response to light touch of the affected region, such that sexual function and other activities can be severely limited. Medical costs associated with vulvodynia are high, exceeding $21 billion annually in the United States （Xie et al., 2012）. The high level of direct medical costs has been linked to high treatment failure rates. Many women with the disorder consult multiple practitioners and undergo multiple courses of treatment with limited benefit.