Mechanical model of vulnerable atherosclerotic plaque rupture

作     者：SU Haijun1, ZHANG Mei2 & ZHANG Yun2 1. School of Mathematics and System Science, Shandong University, Jinan 250100, China 2. Qilu Hospital, Shandong University, Jinan 250012, China 

作者机构：School of Mathematics and System Science Shandong University Jinan China Qilu Hospital Shandong University Jinan China 

出 版 物：《Science China(Physics,Mechanics & Astronomy)》 (中国科学：物理学、力学、天文学（英文版）)

年 卷 期：2004年第47卷第4期

页      面：452-462页

核心收录：

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

基　　金：supported by the National Natural Science Foundation of China(Grant Nos.10302016 and 60271015) the Key Foundation of Health Ministry of China(Grant No.20012943) the Natural Science Foundation of Shandong University 

主　　题：fibrous cap, parametric resonance, stability, mechanism, identification. 

摘      要：Rupture of atherosclerotic plaque is the main trigger of acute cardiovascular events, but the mechanism of plaque rupture is still unknown. We have constructed a model describing the motion of the fibrous cap of the plaque using the theory of elastic mechanics and studied the stability of the plaque theoretically. It has shown that plaque rupture is the result of a dynamic interplay between factors intrinsic to the plaque itself and extrinsic factors. We have proposed a new mechanism of plaque rupture, given a new explanation about the nonlinear dynamic progress of atherosclerosis and suggested a method to identify the vulnerable plaques to manage atherosclerosis.