Dopamine receptor D2 polymorphism is associated with alleviation of obesity after 8-year follow-up: a retrospective cohort study in obese Chinese children and adolescents

作     者：Jian-fang ZHU Lian-hui CHEN Ke YUAN Li LIANG Chun-lin WANG 

作者机构：Department of Pediatricsthe First Affiliated HospitalZhejiang University School of MedicineHangzhou 310003China The Second Affiliated Hospital of Fujian Medical UniversityQuanzhou 362000China 

出 版 物：《Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)》 (浙江大学学报（英文版）B辑（生物医学与生物技术）)

年 卷 期：2018年第19卷第10期

页      面：807-814页

核心收录：

学科分类：1002[医学-临床医学] 100202[医学-儿科学] 10[医学] 

基　　金：Project supported by the National Natural Science Foundation of China(No.11571309) the National Key Research and Development Programme of China(No.2016YFC1305301) the Jin Lei Pediatric Endocrinology Growth Research Fund for Young Physicians(No.PEGRF201405001),China 

主　　题：Obesity Follow-up study Dopamine receptor D2 Children Adolescent 

摘      要：Objective： The aim of this study was to explore the association of dopamine receptor D2 （DRD2） polymorphism and alleviation of obesity in children and adolescents after 8-year follow-up. Methods： This retrospective cohort study included obese children and adolescents with a follow-up period of 8 years. Baseline clinical character- istics and DRD2 polymorphisms （including rs1076562, rs2075654, and rs4586205） were extracted from medical records. A follow-up visit was performed in May 2017 to collect related data including height, weight, diet compliance, and exercise compliance. Results： One hundred and nine obese children and adolescents were included in the current study. Among three DRD2 single nucleotide polymorphisms, only rs2075654 had a statistically significant association with alleviation of obesity, as the alleviation rate for minor allele carders （68.6% for TC＋TT） was higher compared to the major allele homozygote （43.3% for CC）. After adjusting for all related factors, the hazard ratio of rs2075654 minor allele carders for the alleviation of obesity was 3.34 （95% confidence interval （CI）： 1.30-8.58）. Conclusions： The rs2075654 ~olvmomhism of DRD2 is related to Ionq-term obesity alleviation in obese Chinese children and adolescents.