MicroRNAs and Type 2 Diabetes/Obesity

作     者：Mustafa Abdo Saif Dehwah Aimin Xu Qingyang Huang 

作者机构：Hubei Key Lab of Genetic Regulation and Integrative BiologyCollege of Life SciencesCentral China Normal UniversityWuhan 430079China Department of MedicineThe University of Hong KongHong KongChina 

出 版 物：《Journal of Genetics and Genomics》 (遗传学报（英文版）)

年 卷 期：2012年第39卷第1期

页      面：11-18页

核心收录：

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

基　　金：supported by the National Basic Research Program of China(973 Program)(No.2011CB504004) and self-determined research funds of CCNU from the colleges' basic research and operation of MOE 

主　　题：MicroRNAs Type 2 diabetes Obesity 

摘      要：MicroRNAs belong to a newly identified class of small non-coding RNAs that have been widely implicated in the fine-tuning of many physiological processes such as the pathogenesis of type 2 diabetes （T2D） and obesity. Microarray studies have highlighted an altered profile of miRNA expression in insulin target tissues in diabetic and obese models. Emerging evidences suggest that miRNAs play significant roles in insulin production, secretion and actions, as well as in diverse aspects of glucose homeostasis and adipocyte differentiation. The identification of tissue-specific miRNAs implicated in T2D and obesity might be useful for the future development of effective strategies for early diagnosis and therapeutic intervention of obesity-related medical complications.