复发性感染综合征患者皮肤黏膜感染的流行病学评估

作     者：Orrego J.C. Montoya C.J. Gó mez R.D. 焦婷 

作者机构：Dr. Grupo de Immunodeficiencias Primarias Facultad de Medicina Universidad de Antioquia Carrera 51D Medelln SA Colombia 

出 版 物：《世界核心医学期刊文摘(皮肤病学分册)》 (Digest of the World Core Medical Journals)

年 卷 期：2005年第12期

页      面：61-62页

学科分类：1004[医学-公共卫生与预防医学(可授医学、理学学位)] 100401[医学-流行病与卫生统计学] 10[医学] 

摘      要：Background: Recurrent infection syndrome (RIS) results from repeated interactions between hosts and environmental infectious agents and is considered normal (NRIS) because of its benign evolution and positive effects in the development of normal immune responses. Abnormal RIS (ARIS) is characterized by the unusually high frequency of severe infections, either as a result of anatomical or functional abnormalities or due to primary or secondary immunodeficiencies (PIDs and SIDs, respectively). Recurrent mucocutaneous infections (MCIs) can be manifestations of RIS or ARIS and could bemore frequent in primary immunodeficiencies. Similarly, etiologic agents might vary from what is observed in the general population. Methods: We carried out a descriptive study to determine the prevalence of aerobic bacterial and fungal mucocutaneous infections in 452 patients with recurrent infections, using clinical records to establish immunological status associated with the presence and characteristics of the infections. Microbiological analyses from mucocutaneous lesions were used to confirm the etiology. Results: We found mucocutaneous infections in 50 patients for a total of 62 episodes (bacterial or fungal infections in 38 vs. 12 patients, respectively). Mucocutaneous infections were more frequent (21.8% vs. 9.1% ; OR=2.8) and recurrent (8.7% vs. 0.2% ; P=0.000) in primary immunodeficient patients. Furthermore, those with defects in phagocytic cells presented more mucocutaneous infections (56.2% ) than patients with other primary immunodeficiencies (11.3% ; OR=10.1). Conclusions: Bacterial and fungal mucocutaneous infections are more frequent and severe in primary immunodeficient patients, particularly those with defective phagocytosis. Early and adequate assessment of the nature of mucocutaneous infections in ARIS should impact the ability of physicians to treat promptly, avoid complications and reduce the costs of medical assistance. 