Advances in the antitumor activities and mechanisms of action of steroidal saponins

作     者：ZHAO Ya-Zheng ZHANG Yuan-Yuan HAN Han FAN Rui-Ping HU Yang ZHONG Liang KOU Jun-Ping YU Bo-Yang 

作者机构：Jiangsu Key Laboratory of TCM Evaluation and Translational ResearchDepartment of Complex Prescription of Traditional Chinese MedicineChina Pharmaceutical University 

出 版 物：《Chinese Journal of Natural Medicines》 (中国天然药物（英文版）)

年 卷 期：2018年第16卷第10期

页      面：732-748页

核心收录：

学科分类：0710[理学-生物学] 1007[医学-药学(可授医学、理学学位)] 1006[医学-中西医结合] 1005[医学-中医学] 100706[医学-药理学] 1002[医学-临床医学] 0703[理学-化学] 100602[医学-中西医结合临床] 10[医学] 

基　　金：supported by the National Natural Science Foundation of China(No.81503295) 2011 Program for Excellent Scientific and Technological Innovation Team of Jiangsu Higher Education Funded by the Priority Academic Program Development of Jiangsu Higher Education Institutions Jiangsu Province 2011 Plan for Collaborative Innovation 

主　　题：Steroidal saponins Tumor Mechanism 

摘      要：The steroidal saponins are one of the saponin types that exist in an unbound state and have various pharmacological activities,such as anticancer,anti-inflammatory,antiviral,antibacterial and nerves-calming *** is a growing health problem *** progress has been made to understand the antitumor effects of steroidal saponins in recent *** to reported findings,steroidal saponins exert various antitumor activities,such as inhibiting proliferation,inducing apoptosis and autophagy,and regulating the tumor microenvironment,through multiple related signaling *** article focuses on the advances in domestic and foreign studies on the antitumor activity and mechanism of actions of steroidal saponins in the last five years to provide a scientific basis and research ideas for further development and clinical application of steroidal saponins.