Pathogenicity of Rabies Viruses Isolated in China: Two Fixed Strains and a Street Strain

作     者：HUANG Ying TANG Qing Simon RAYNER GONG Kai SONG Bo LIANG Guo Dong 

作者机构：Key Laboratorg for Medical Virology Ministry of Health Institute for Viral Disease Control and Prevention Chinese Center for Disease Control and Prevention (IVDC China CDC) State Key Laboratory for Virology Wuhan Institute of Virology Chinese Academy of Sciences State Key Laboratory of Biomembrane and Membrane Biotechnology School of Life Sciences Tsinghua University State Key Laboratory for Infectious Disease Prevention and Control Institute for Viral Disease Control and PreventionChina CDC 

出 版 物：《Biomedical and Environmental Sciences》 (生物医学与环境科学（英文版）)

年 卷 期：2013年第26卷第7期

页      面：552-561页

核心收录：

学科分类：090603[农学-临床兽医学] 090601[农学-基础兽医学] 0830[工学-环境科学与工程（可授工学、理学、农学学位）] 1004[医学-公共卫生与预防医学(可授医学、理学学位)] 1001[医学-基础医学(可授医学、理学学位)] 09[农学] 0906[农学-兽医学] 

基　　金：supported in part by the National Department Public Benefit Research Foundation(200803014) the National Science and Technology Key Projects(2008ZX10004-008) the Major Program of National Natural Science Foundation of China(30630049) the Key Technologies Research and Development Program of China(2009ZX10004-705) the China postdoctoral science foundation project 

主　　题：Rabies Virus Pathogenicity Distribution Glycoprotein 

摘      要：Objective To investigate the virulence characteristics of two fixed strains （CTN and aG） and a street strain （HNIO） of rabies viruses isolated in China, Methods ICR mice of different age groups were via the intracracerebral （i.c.） or intramuscular （i.m inoculated with CTN, aG and HN10 rabies virus strains ） routes, and observed for 20 days. Results The CTN strain was pathogenic to 7-day-old suckling mice that received i.c. inoculations and 3-day-old suckling mice that received i.m. inoculations. The aG strain was pathogenic to 4-week-old mice that received i.c. inoculations and 7-day-old suckling mice that received i.m. inoculations. The HN10 strain was pathogenic to mice of all age groups via both inoculation routes. In moribund mice, the viruses had spread to most regions of the brain. The CTN and HN10 strains had similar dissemination patterns in the brain; both viral antigens could be found in the dentate gyrus （DG）, whereas few viral antigens were present in the DG from specimens that had been infected with the aG strain. Conclusion A comprehensive sequence analysis of the G protein suggested that differences in gene sequences may be responsible for producing strain-specific differences in pathogenicity and distribution in the brain.