Sympathetically evoked Ca2+signaling in arterial smooth muscle

作     者：Joseph ZACHARIA Christine LAMONT Withrow Gil WIER 

作者机构：Department of PhysiologyUniversity of Maryland School of MedicineBaltimoreMaryland 21201USA Department of PharmacologyKey Laboratory of Environment and Genes Related to Diseases of Ministry of EducationSchool of MedicineXi-an Jiaotong UniversityXi-an 710061China Department of PhysiologyUniversity of Maryland School of MedicineBaltimoreMerryland 21201USA 

出 版 物：《Acta Pharmacologica Sinica》 (中国药理学报(英文版))

年 卷 期：2006年第27卷第12期

页      面：1515-1525页

核心收录：

学科分类：1007[医学-药学(可授医学、理学学位)] 1002[医学-临床医学] 1001[医学-基础医学(可授医学、理学学位)] 10[医学] 

基　　金：NationalInstitutesofHealth(USA)(Grant№HL64708) TheNationalNaturalScienceFoundationofChina(№30470633) theResearchFundfortheDoctoralProgram(№20050698012) 

主　　题：sympathetic nerve Ca2+ signaling arterial smooth muscles receptors junctional Ca2+ transients confocal microscope 

摘      要：The sympathetic nervous system plays an essential role in the control of totalperipheral vascular resistance and blood flow,by controlling the contraction ofsmall *** sympathetic nerves release ATE norepinephrine（NE）and neuropeptide *** review summarizes our knowledge of the intracellularCa2+signals that are activated by ATP and NE,acting respectively on P2X1and α1-adrenoceptors in arterial smooth *** neurotransmitter produces a uniquetype of post-synaptic Ca2+signal and associated *** neural releaseof ATP and NE is thought to vary markedly with the pattern of nerve activity,probably reflecting both pre-and post-synaptic ***,we showthat Ca2+signaling during neurogenic contractions activated by trains of sympa-thetic nerve fiber action potentials are in fact significantly different from thatelicited by simple bath application of exogenous neurotransmitters to isolatedarteries（a common experimental technique）,and end by identifying importantquestions remaining in our understanding of sympathetic neurotransmission andthe physiological regulation of contraction of small arteries.