非损伤性激光治疗后真皮基质重塑

作     者：Orringer J.S. Voorhees J.J. Hamilton T. 焦婷 

作者机构：University of Michigan Health System 1910 TaubmanCenter 1500 E MedicalCenter Dr AnnArborMI 48109- 0314United StatesDr. 

出 版 物：《世界核心医学期刊文摘（皮肤病学分册）》 (Digest of the World Core Medical JOurnals:Dermatology)

年 卷 期：2006年第2卷第2期

页      面：6-7页

学科分类：1002[医学-临床医学] 100206[医学-皮肤病与性病学] 10[医学] 

主　　题：非损伤性 前胶原 光损伤 活检标本 细胞因子 雅克 RNA 

摘      要：Objective: Nonablative laser therapy is widely practiced for cutaneous rejuvenation. We sought to quantify dermal molecular changes after exposure of photodamaged skin to nonablative laser energy. Methods: Nonablative laser therapy of forearm skin using either a 585- nm wavelength pulsed dye laser or a 1320- nm wavelength neodymium:yttrium- aluminum- garnet laser was performed. Serial biopsy specimens were obtained at baseline and various times after treatment. Results: Statistically significant increases in type I procollagen messenger RNA expression occurred after exposure of photodamaged skin to each laser. Induction was 47% (P .05) and 84% (P .05)- above baseline levels 1 week after laser therapy among those treatedwith the pulsed dye and neodymium:yttrium- aluminumgarnet lasers, respectively. Substantial induction of type III procollagen, various matrix metalloproteinases, and primary cytokines was also demonstrated. Responses with respect to all molecules studied were highly variable. Limitations: This study addresses molecular changes after a single laser exposure whereas clinically, serial treatments are often provided. Conclusions: Nonablative laser therapy may result in quantifiable alterations in molecules associated with remodeling of the dermal matrix, although responses vary greatly among patients.