Evidence-based medicine and precision medicine:complementary approaches to clinical decision-making
作者机构：Department of Health Research MethodsEvidence and ImpactMcMaster UniversityHSC-2C1280 Main St.WestHamiltonOntarioL8S 4K1Canada The Michael G.DeGroote Institute for Pain Research and CareMcMaster UniversityMDCL-21011280 Main St.WestHamiltonOntarioL8S 4K1Canada Department of MedicineMcMaster University4V331280 Main St.WestHamiltonOntarioL8N 3Z5Canada Department of AnesthesiaMcMaster UniversityHSC-2V91280 Main St.WestHamiltonOntarioL8S 4K1Canada The Michael G.DeGroote Centre for Medicinal Cannabis ResearchMcMaster University1280 Main St.WestHamiltonOntarioL8S 4K1Canada
出 版 物：《Precision Clinical Medicine》 (精准临床医学（英文）)
年 卷 期：2018年第1卷第2期
页 面：60-64页
学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学]
主 题：evidence-based medicine precision medicine decision-making
摘 要：Evidence-based medicine is widely promoted for decision-making in health care and is associated with improved patient *** have suggested that evidence-based medicine focuses primarily on groups of patients rather than individuals,but often fail to consider subgroup analyses,N-of-1 trials,and the incorporation of patient values and *** medicine has been promoted as an approach to individualize diagnosis and treatment of diseases through genetic,biomarker,phenotypic,and psychosocial ***,there are often high costs associated with personalized medicine,and high-quality evidence is lacking for effectiveness in many *** the potential of personalized medicine to be realized,it must adhere to the principles of evidencebased medicine:(1)evidence in isolation is not sufficient to make clinical decisions—patient’s values and preferences as well as resource implications must be considered,and(2)there is a hierarchy of evidence to guide clinical decision-making and studies at lower risk of bias are likely to provide more trustworthy findings.
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