Research advances in gene therapy for Parkinson's disease

作     者：MA Duanduan WANG Xiaomin HAN Jisheng 

作者机构：Neuroscience Research InstituteBeijing Medical UniversityBeijing 100083China. 

出 版 物：《Chinese Science Bulletin》 (Chin. Sci. Bull.)

年 卷 期：1998年第43卷第5期

页      面：363-368页

核心收录：

学科分类：1002[医学-临床医学] 100204[医学-神经病学] 10[医学] 

基　　金：ThisstudywassupportedbytheNationalNaturalScienceFoundationofChina (GrantNo .39480 0 0 8)  theTrans_CenturyTrainingProgrammeFoundationfortheTalentsofStateEducationCommissionofChinaandNorthAmericanMedi calAssociationFoundationofHongKong 

主　　题：Parkinsion's disease(PD) gene therapy tyrosine hydroxylase(TH) GDNF virus vector 

摘      要：During the long period of time when people have been seeking for an effective therapeutic method for PD, the gene therapy has shown greater and greater advantages over other methods. It can be performed mainly in two ways: ex vivo and in vivo. With the former, TH gene as well as some neurotrophic factor genes (such as GDNF, BNDF genes) can be invited to some cell lines or primary cells thus forming engineered cells and then implanting them into brain. While with the latter, viral vectors including HSV-1, Ad, AAV that can be utilized to construct recombinant viruses, or non-virus vectors can be used to delived DNA into brain directly. The present review summarizes the recent research advances in the gene therapy for PD, and it is reasonable for us to predict a notable progress in prevention and treatment for PD in the next decade.