Fibrogenesis in inflammatory bowel disease——A bright road ahead

作     者：Florian Rieder Claudio Fiocchi Rieder Florian;Claudio Fiocchi

作者机构：Department of PathobiologyLerner Research InstituteDepartment of GastroenterologyHepatology and Nutrition Digestive Disease and Surgery Institute Cleveland ClinicClevelandUSA 

出 版 物：《中华炎性肠病杂志（中英文）》 (Chinese Journal of Inflammatory Bowel Diseases)

年 卷 期：2018年第2卷第1期

页      面：3-4页

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

主　　题：Fibrogenesis ahead stenosis 

摘      要：Intestinal fibrosis is a frequent complication of inflammatory bowel diseases (IBD),and can lead to stricture formation and intestinal obstruction. Clinically apparent stenosis occurs in more than 30% of patients with Crohn s disease (CD) and about 5%~10% of patients with ulcerative colitis (UC) [l -2],and its management represents an important and frequent challenge in clinical practice. Despite its tremendous clinical impact the tools we currently have to address this challenge are limited (l)Anti-inflammatory therapies are only a temporizing measure to relieve obstruction and re-obstruction is frequent, necessitating endoscopic balloon dilation or surgical intervention(3 5)No specific anti-fibrotic therapy exists at present, and therefore it is critical to understand the mechanisms of intestinal fibrogenesis to develop targeted therapeutic approaches.