Four-year follow-up of endoscopic gastroplication for the treatment of gastroesophageal reflux disease

作     者：Matthijs P Schwartz J Rieneke C Schreinemakers André J P M Smout 

作者机构：Department of GastroenterologyMeander Medical Center Department of GastroenterologyUniversity Medical Center 

出 版 物：《World Journal of Gastrointestinal Pharmacology and Therapeutics》 (世界胃肠药理与治疗学杂志（英文版）（电子版）)

年 卷 期：2013年第4卷第4期

页      面：120-126页

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

主　　题：Endoscopic therapy Endocinch Gastroesophageal Reflux Gastroplication Follow-up studies 

摘      要：AIM:To evaluate the long-term effect of Endocinch treatment for gastroesophageal reflux disease(GERD).METHODS:After unblinding and crossover,50 patients(32 males,18 females; mean age 46 years) with pH-proven chronic GERD were recruited from an initial randomized,placebo-controlled,single-center study,and included in the present prospective open-label follow-up ***,three gastroplications using the Endocinch device were placed under deep sedation in a standardized *** retreatment was offered in the first year with 1 or 2 extra *** baseline,3 mo after(re) treatment and yearly proton pump inhibitor(PPI) use,GERD symptoms,quality of life(QoL) scores,adverse events and treatment failures(defined as:patients using 50% of their baseline PPI dose or receiving alternative antireflux therapy) were ***-to-treat analysis was ***:Median follow-up was 48 mo [interquartile range(IQR):38-52].Three patients were lost to *** 44% of patients retreatment was done after a median of 4 mo(IQR:3-8).No serious adverse events *** the end of follow-up,symptom scores and4 out of 6 QoL subscales were improved(all P 0.01compared to baseline).However,80% of patients required PPIs for their GERD ***,64% of patients were classified as treatment *** 60% a post-procedural endoscopy was carried out,of which in 16% reflux esophagitis was ***:In the 4-year follow-up period,the subset of GERD patients that benefit from endoscopic gastroplication kept declining gradually,nearly half opted for retreatment and 80% required PPIs eventually.