Synthesis and Antibacterial Activities of Pyran Annulated Heterocyclic Compounds

作     者：曲迪 刘振 李靖 罗晓星 李明凯 

作者机构：Department of Pharmacology School of Pharmacythe Fourth Military Medical University School of Chemistry and Chemical Engineering Xi’an University 

出 版 物：《Chinese Journal of Structural Chemistry》 (结构化学（英文）)

年 卷 期：2015年第34卷第2期

页      面：185-188页

核心收录：

学科分类：1007[医学-药学(可授医学、理学学位)] 081704[工学-应用化学] 07[理学] 08[工学] 0817[工学-化学工程与技术] 070303[理学-有机化学] 0703[理学-化学] 10[医学] 

基　　金：supported by the Innovation plan of science and technology of Shaanxi Province(2014KTCL03-03) 

主　　题：pyran, crystal, staphylococcus aureus, minimum inhibitory concentration 

摘      要：Two novel pyran annulated heterocyclic compounds （1 and 2） were synthesized and characterized via IR, lH NMR and H RMS. The structure of compound 1 was verified by single-crystal X-ray diffraction. The in vitro antibacterial activities of the two compounds against Staphylococcus aureus （S. aureus ATCC 29213）, methicillin-resistant S. aureus （MRSA XJ 75302）, vancomycin-intermediate S. aureus （Mu50 ATCC 700699）, and USA 300 （Los Angeles County clone, LAC） were evaluated by observing the minimum inhibitory concentration.