Assesment of polyunsaturated fatty acids in cord blood of infants of diabetic mothers

作     者：Galila M Mokhar Soha M Abd El Dayem Nermine H Sayed Sohair abd El Maksod Manal El Shamaa Hani M El Mikaty 

作者机构：Pediatrics DepartmentClinical Pathology DepartmentAin Shams University National Research CenterCairoEgypt 

出 版 物：《海南医学院学报》 (Journal of Hainan Medical University)

年 卷 期：2009年第15卷第11期

页      面：1370-1378,1386页

学科分类：12[管理学] 1204[管理学-公共管理] 120402[管理学-社会医学与卫生事业管理(可授管理学、医学学位)] 1004[医学-公共卫生与预防医学(可授医学、理学学位)] 1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

主　　题：糖尿病 诊断方法 婴儿 保健知识 

摘      要：Objective:To assess whether infants of diabetic mothers [pre pregnancy diabetics(PPD)and gestational diabetics mellitus(GDM)] have compromised arachidonic and docosahexaenoic acids in their plasma and the relationship with deficiency of the same compounds in their ***:This study was conducted on 30 diabetic mothers(both PPD and GDM)and their *** healthy infants and their mothers with age and sex matched were included as *** infant(of diabetic and non diabetic mothers)were subjected to assessment of APGAR Scoring,thorough history taking and anthropometric *** profile components as well as polyunsaturated fatty acids(PUFA)were assessed in diabetic GDM and PPD and non diabetic mothers as well as in their ***:High-density lipoproteir(HDL)level was found to be significantly lower in diabetic mothers(specially those with PPD)compared to non diabetic ones,whereas no significant difference was found between babies of the two ***,the current study revealed that diabetic mothers(GDM and PPD)and their babies had significantly higher levels of PUFA precursors linoleic acids(LA)and alpha linoleic acids(ALA).PUFA arachidonic acid(AA)and docosahexaenoic acids(DHA)were found to be significantly lower in diabetic mothers(GDM and PPD)compared to non diabetic mothers,and same results were found in the babies of the two ***:Neonates with diabetic mothers(both GDM and PPD)have highly compromised plasma levels of AA and DHA PUFA,which affects the child well being by far,and produces hazardous multi-system complications on the long run.