In vivo antioxidant effect of aqueous root bark,stem bark and leaves extracts of Vitex doniana in CCl_4 induced liver damage rats

作     者：Kadejo Olubukola Adetoro James Dorcas Bolanle Sallau Balarebe Abdullahi Ozigi Abdulrahaman Ahmed 

作者机构：Department of BiochemistryAhmadu Bello University 

出 版 物：《Asian Pacific Journal of Tropical Biomedicine》 (亚太热带生物医学杂志（英文版）)

年 卷 期：2013年第3卷第5期

页      面：395-400页

学科分类：0710[理学-生物学] 0831[工学-生物医学工程（可授工学、理学、医学学位）] 1008[医学-中药学(可授医学、理学学位)] 1006[医学-中西医结合] 100602[医学-中西医结合临床] 10[医学] 

基　　金：Supported by Department of Biochemistry Ahmadu Bello University Zaria Nigeria(Grant No.2010-2011/05488) 

主　　题：Antioxidant Vitex doniana Carbon tetrachloride 

摘      要：Objective:The antioxidant effects of aqueous root bark,stem bark and leaves of Vitex doniana(***)were evaluated in carbon tetrachloride(CCl_4)induced liver damage and non induced liver damage albino ***:A total of 60 albino rats(36 induced liver damage and 24 non induced liver damage)were assigned into liver damage and non liver damage groups of 6 rats in a *** animals in the CCl_4 induced liver damage groups,were induced by intraperitoneal injection with a single dose of CCl_4(148mg·ml^(-1)·kg^(-1)body weight)as a 1:1(v/v)solution in olive oil and were fasted for 36 h before the subsequent treatment with aqueous root bark,stem bark and leaves extracts of *** and vitamin E as standard drug(100 mg/kg body weighy per day)for 21 d,while the animals in the non induced groups were only treated with the daily oral administration of these extracts at the same *** administration of CCl_4 was done once a week for a period of three ***:The liver of CCl_4 induced not treated group showed that the induction with CCl_4,significantly(P0.05)difference between TBARS,SOD and CAT in the liver of the induced treated groups and normal control *** the *** showed no significant(P0.05)difference between the normal and the induced groups,SOD was significantly(P0.05)change in the liver and kidney level of TBARS,SOD and CAT compared with the normal control except in the kidney of animals treated with stem extract where TBARS was significantly(P0.05)lowered compare