Altered leukocyte gene expression after traumatic spinal cord injury:clinical implications

作     者：Paige E.Herman Ona Bloom 

作者机构：The Feinstein Institute for Medical ResearchNorthwell Health Departments of Physical Medicine and RehabilitationMolecular MedicineDonald and Barbara Zucker School of Medicine at Hofstra Northwell 

出 版 物：《Neural Regeneration Research》 (中国神经再生研究（英文版）)

年 卷 期：2018年第13卷第9期

页      面：1524-1529页

核心收录：

学科分类：0710[理学-生物学] 1002[医学-临床医学] 1001[医学-基础医学(可授医学、理学学位)] 10[医学] 

基　　金：supported by grants from the Craig H.Neilsen Foundation the NY State Empire Clinical Research Program the NY State Spinal Cord Injury Research Board(grants to OB) 

主　　题：traumatic spinal cord injury inflammation immune cells functional genomics gene expression autoimmunity microarray chronic spinal cord injury 

摘      要：In addition to changes in motor and sensory function, individuals with spinal cord injury （SCI） experience immunological changes. These changes are clinically significant, as infections are the leading cause of death for this population. Along with increased infections, inflammation is commonly observed in persons with SCI, where it may promote many common medical consequences. These include elevated risk of cardio- vascular disease, impaired wound healing, diabetes and neuropathic pain. It has also been proposed that chronic inflammation dampens neurological recovery. In order to identify therapeutic strategies to im- prove immune function, we need a greater understanding of the molecular changes that occur in immune cells after SCI. The purpose of this mini-review is to discuss two recent studies that used functional genom- ics to investigate gene expression in circulating leukocytes isolated from persons with SCI. In the future, the molecular pathways that are altered after SCI may be targeted to improve immunological function, as well as overall health and functional recovery, after SCI.