CdS Quantum Dots as Fluorescence Probes for Detection of Adriamycin Hydrochloride

作     者：LIAO Qie-gen LI Yuan-fang HUANG Cheng-zhi 

作者机构：College of Chemistry and Chemical Engineering Southwest UniversityChongqing 400715 P. R. China 

出 版 物：《Chemical Research in Chinese Universities》 (高等学校化学研究（英文版）)

年 卷 期：2007年第23卷第2期

页      面：138-142页

核心收录：

学科分类：1007[医学-药学(可授医学、理学学位)] 081704[工学-应用化学] 07[理学] 08[工学] 0817[工学-化学工程与技术] 070302[理学-分析化学] 0703[理学-化学] 10[医学] 

基　　金：the National Natural Science Foundation of China(No 30570465) the Municipal Science and Technology Committee of Chongqing 

主　　题：Fluorescence quenching CdS quantum dots Adriamycin 

摘      要：Water-soluble CdS quantum dots（CdS-QDs） capped with thioglycohc acid were easily prepared, and a detection method of adriamycin was presented based on the fluorescence quenching of CdS-QDs. It was found that a complex could be formed between cetyhrimethyl ammonium bromide（CTAB） and CdS-QDs by using electrostatic interaction in Britton-Robinson（BR） buffer at pH = 7.00, and the strong fluorescence emission of the complex was observed at 500 nm when the complex was excited at 378 run. The presence of adriamycin, however, could strongly quench the fluorescence through hydrophobic interaction. The overall quenching percentage as a function of adriamycin concentration matches the Stern-Volmer equation very well. These properties make CdS-QDs a potential fluorescence probe for the detection of adriamycin. The detection hmit（3σ） of adriamycin is approximately 10^-9 mol/L.