Differences between hepatic and biliary lipid metabolism and secretion in genetically gallstone-susceptible and gallstone-resistant mice

作     者：许国强 赵力 Michael Fuchs XU Guoqiang;ZHAO Li;Michael Fuchs

作者机构：浙江大学医学院附属第一医院消化科杭州310003 浙江大学医学院附属第一医院心内科杭州310003 Department of Medicine 

出 版 物：《Chinese Medical Journal》 (中华医学杂志（英文版）)

年 卷 期：2002年第115卷第9期

页      面：1292-1295,143页

核心收录：

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

基　　金：ThisprojectwassupportedbyagrantfromtheNationalEducationCommitteeFundforStudentsStudyingAbroad (No .G5 0 0 40 ) 

主　　题：Genetic Predisposition to Disease Lipid Metabolism Animals Bile Cholelithiasis Cholesterol Fatty Liver Liver Male Mice Mice, Inbred AKR Mice, Inbred C57BL Research Support, Non-U.S. Gov't 

摘      要：OBJECTIVE: To investigate differences between hepatic and biliary lipid metabolism and secretion of genetically gallstone-susceptible (C57L) and resistant (AKR) mice and the mechanism of cholesterol gallstone formation. METHODS: The inbred C57L and AKR mice were fed a lithogenic diet containing 15% fat, 1.25% cholesterol and 0.5% cholic acid for four weeks. Hepatic cholesterol content and secretion rates of biliary lipids, as well as phenotypes of the liver and gallbladder were determined and examined before and after the feeding of the lithogenic diet. RESULTS: Both before and after ingestion of the lithogenic diet, hepatic secretion rates of all biliary lipids in C57L mice were markedly higher than that of AKR mice (P