Protective Efficacy of Calcium Channel Blockers in Sulphur Mustard Poisoning

作     者：P.K.MAZMDER K.SUGENDRAN 等 

作者机构：DerenceResearchandDevelopmentEstablishmentGwaliou－474002India DerenceResearchandDevelopmentEstablis 

出 版 物：《Biomedical and Environmental Sciences》 (生物医学与环境科学（英文版）)

年 卷 期：1998年第11卷第4期

页      面：363-369页

核心收录：

学科分类：1002[医学-临床医学] 1009[医学-特种医学] 10[医学] 

主　　题：投药 皮肤 解毒药/治疗应用 钙通道阻滞药/治疗应用 化学战药物/中毒 药物评价 临床前 半数致死量 芥子气/中毒 硝苯地平/治疗应用 存活率 动物 男(雄)性 小鼠 

摘      要：The present study was designed to ascertain the in vivo protective efficacy of Ca2+ channel blockers against dermally applied sulphny mustard (SM). Male albino mice were exposed to 1. 5 LD50 of SM (232 mg/kg) percutaneously and the control group received an equal volume of vehicle (polyethylene glycol 300). Prior to SM application, the animals were administered nifedipine and dextrose saline containing antibiotic by intraperitoneal route. The protection assessed by the mean survival time (MST) was determined by Dunnett s method. The MST was significantly increased in nifedipine treated *** characteristic biochemical indices of SM intoxication, i. e. lipid peroxidation and reduced glutathione (GSH) were determined in liver from animals sacrificed at 24, 48 and 72 h after exposure. SM application (1 LD50) caused a reduction in GSH level which was restored in nifedipine treated group. SM-induced lipid peroxidation was also prevented by nifedipine administration. The protective effect of nifedipine may be related to its capacity of attenuating SM-induced lipid peroxidation and glutathione depletion