Optimization for supercritical CO2 extraction of icariin by response surface method

作     者：Ya-Qiong Guan Yao-Wu Zhang Long Zhang 

作者机构：Department of Pharmacy College of Chemical Engineering Qingdao University of Science and Technology Qingdao 266042 China 

出 版 物：《Journal of Chinese Pharmaceutical Sciences》 (中国药学（英文版）)

年 卷 期：2011年第20卷第2X期

页      面：159-163页

学科分类：1008[医学-中药学(可授医学、理学学位)] 1007[医学-药学(可授医学、理学学位)] 1006[医学-中西医结合] 100602[医学-中西医结合临床] 10[医学] 

主　　题：Central composite design Herba Epimedii Icariin Response surface method Supercritical fluid extraction 

摘      要：The aim of the present study was to optimize the supercritical CO 2 extraction conditions of icariin from Herba Epimedii by response surface method (RSM) and central composite design (CCD). A 3-factor, 5-level CCD was used for the optimization. Independent variables were extraction temperature, extraction pressure and entrainer flow rate. Dependent variable was yield ratio of icariin from Herba Epimedii. A two-order polynomial equation was fitted to the data. The results showed that the optimum extraction conditions were as follows: extraction temperature 46.5 °C, extraction pressure 30.6 MPa, entrainer flow rate 3.3 mL/min. CCD/ RSM is convenient and highly predictive for optimizing the extraction process of icariin from Herba Epimedii. © 2011 Journal of Chinese Pharmaceutical Sciences, School of Pharmaceutical Sciences, Peking University.