Amphiphilic poly(ethylene glycol)-b-poly(ethylene brassylate)copolymers: One-pot synthesis, self-assembly, and controlled drug release

作     者：Jiu-Cun Chen Jun-Zhi Li Jian-Hua Liu Li-Qun Xu 

作者机构：Institute for Clean Energy & Advanced Materials Southwest University State Key Laboratory of Medicinal Chemical Biology Nankai University Chongqing Key Laboratory for Advanced Materials & Technologies of Clean Energies 

出 版 物：《Chinese Chemical Letters》 (中国化学快报（英文版）)

年 卷 期：2015年第26卷第10期

页      面：1319-1321页

核心收录：

学科分类：1007[医学-药学(可授医学、理学学位)] 081704[工学-应用化学] 07[理学] 08[工学] 0817[工学-化学工程与技术] 070305[理学-高分子化学与物理] 080501[工学-材料物理与化学] 0805[工学-材料科学与工程（可授工学、理学学位）] 0703[理学-化学] 10[医学] 

基　　金：supported by the Open Fund of State Key Laboratory of Medicinal Chemical Biology (Nankai University) under grant 20140523 the Fundamental Research Funds for the Central Universities (Nos. SWU 113075 and XDJK2014B015) 

主　　题：Poly(ethylene brassylate) Self assembly Nanoparticles Controlled drug release 

摘      要：A set of amphiphilic poly（ethylene glycol）-b-poly（ethylene brassylate）（PEG-b-PEB） copolymers based on the PEB hydrophobic block was first synthesized by ring-opening polymerization of ethylene brassylate with an organic catalyst. The EB/PEG molar ratios and reaction times were adjusted to achieve different chain lengths of PEB. Block copolymers that were characterized by1 H NMR and GPC could selfassemble into multimorphological aggregates in aqueous solution, which were characterized by DLS and TEM. The hydrophobic doxorubicin（DOX） was chosen as a drug model and successfully encapsulated into the nanoparticles. The release kinetics of DOX were investigated.