Progress on the pharmacological research of puerarin: a review

作     者：WEI Shu-Yong CHEN Yi XU Xiao-Yu 

作者机构：Pharmaceutical College of Southwest University & College of Chinese Medicine Chongqing Engineering Research Center for Pharmacodynamics Evaluation Rongchang Campus of Southwest University 

出 版 物：《Chinese Journal of Natural Medicines》 (中国天然药物（英文版）)

年 卷 期：2014年第12卷第6期

页      面：407-414页

核心收录：

学科分类：0710[理学-生物学] 1007[医学-药学(可授医学、理学学位)] 1006[医学-中西医结合] 1005[医学-中医学] 100706[医学-药理学] 1002[医学-临床医学] 0703[理学-化学] 100602[医学-中西医结合临床] 10[医学] 

基　　金：supported by the Ministry of Education Doctoral Program special fund(No.20110182110012) the Key Projects of Chinese Medicine Research of Chongqing Municipal Health Bureau(20102010-1-4) the Fundamental Research Funds for Central Universities(Nos.XDJK2014C058,XDJK2010C059) 

主　　题：Puerarin Cardiovascular protection Neuroprotection Osteoporosis Liver injury Inflammation 

摘      要：Contemporary pharmacological research has demonstrated that puerarin, the most important phytoestrogen extracted from Pueraria lobata(Willd.) Ohwi, has protecting functions on the cardiovascular system, nervous system, osteoporosis, liver injury, and inflammation in vivo and in vitro. Most of these research studies focused on inhibiting oxidative stress and apoptosis through regulating various bioactivators and signal pathways. Among these, superoxide dismutase(SOD), endothelial nitric oxide synthase(eNOS) and malondialdehyde(MDA), and PI3K/Akt, MAPK, and NF-κB are of great importance. The data cited in this review were mainly obtained from articles listed in PubMed and Elsevier SDOL published from 1959 to 2013, and the search term used was puerarin.