Oligodendrocyte-like cell transplantation for acute spinal cord injury

作     者：Yongtao Xu Anmin Chen Feng Li Hougeng Lu 

作者机构：Jingzhou Central Hospital Jingzhou 434020 Hubei Province China Wuhan Tongji Hospital Wuhan 430030 Hubei Province China 

出 版 物：《Neural Regeneration Research》 (中国神经再生研究（英文版）)

年 卷 期：2011年第6卷第16期

页      面：1222-1226页

核心收录：

学科分类：0710[理学-生物学] 090603[农学-临床兽医学] 1002[医学-临床医学] 1001[医学-基础医学(可授医学、理学学位)] 07[理学] 071009[理学-细胞生物学] 09[农学] 0906[农学-兽医学] 0901[农学-作物学] 090102[农学-作物遗传育种] 

主　　题：oligodendrocyte mesenchymal stem cell spinal cord injury transplantation differentiation 

摘      要：In this study, we used insulin-like growth factor-1 to induce bone marrow mesenchymal stem cells （MSCs） to differentiate into oligodendrocyte-like cells. Cell surface marker identification showed that they expressed myelin basic protein and galactosylceramide, two specific markers of oligodendrocytes. These cells were transplanted into rats with acute spinal cord injury at Tt0. At 8 weeks post-implantation, oligodendrocyte-like cells were observed to have survived at the injury site The critical angle of the inclined plane, and Basso, Beattie and Bresnahan scores were all increased. Furthermore, latencies of motion-evoked and somatosensory-evoked potentials were decreased. These results demonstrate that transplantation of oligodendrocytic-induced MSCs promote functional recovery of injured spinal cord.