Synthesis and Biological Activities of Novel s-Triazine Bridged Dinucleoside Analogs

作     者：Shen, Fengjuan Li, Xiaoliu Zhang, Xiaoyuan Qin, Zhanbin Yin, Qingmei Chen, Hua Zhang, Jinchao 

作者机构：Key Laboratory of Chemical Biology of Hebei Province College of Chemistry and Environmental Science Hebei University Baoding Hebei 071002 China College of Science Hebei University of Science & Technology Shijiazhuang Hebei 050018 China 

出 版 物：《Chinese Journal of Chemistry》 (中国化学（英文版）)

年 卷 期：2011年第29卷第6期

页      面：1205-1210页

核心收录：

学科分类：090403[农学-农药学(可授农学、理学学位）] 07[理学] 09[农学] 0904[农学-植物保护] 070303[理学-有机化学] 0703[理学-化学] 

基　　金：Projected supported by the National Basic Research 973 Pre-research Program of China （No. 2010CB534913）  the National Natural Science Foundations of China （NSFC） （Nos. 20672027 and 20972039）  the Natural Science Foundations of Hebei Province （No. B2008000588） and the program of Science and Technology （S ＆ T） of Hebei Province （No. 09276418D-13）. 

主　　题：dinucleoside s-triazine HIV-RT inhibition cyanuric chloride 

摘      要：A series of novel dinucleosides linked by s-triazine were synthesized via the nucleophilic substitution reaction of amino nucleoside and cyanuric chloride in THF/H20. The biological activities of these novel dinucleoside analogs against HIV-RT, HeLa and A-549 cell lines in vitro were evaluated.