5-lipoxygenase expression in a brain damage model induced by chronic oral administration of aluminum

作     者：Yongquan Pan Peng Zhang Junqing Yang Qiang Su 

作者机构：Department of Pharmacology Chongqing Medical University Chongqing 400016 China 

出 版 物：《Neural Regeneration Research》 (中国神经再生研究（英文版）)

年 卷 期：2010年第5卷第21期

页      面：1634-1638页

核心收录：

学科分类：0710[理学-生物学] 1002[医学-临床医学] 1001[医学-基础医学(可授医学、理学学位)] 07[理学] 08[工学] 080104[工学-工程力学] 0815[工学-水利工程] 071003[理学-生理学] 0801[工学-力学（可授工学、理学学位）] 

基　　金：the National Natural Science Foundation of China  No. 30672211 

主　　题：chronic aluminum overload 5-1ipoxygenase brain injury caffeic acid neural regeneration 

摘      要：A preliminary study has found that the 5-lipoxygenase inhibitor, caffeic acid, has a marked protective effect on acute brain injury induced by intracerebroventricular microinjection of aluminum. In this experiment, chronic brain injury and neuronal degeneration model was established in rats by chronic oral administration of aluminum, and then intervened using caffeic acid. Results showed that caffeic acid can downregulate chronic aluminum overload-induced 5-1ipoxygenase mRNA and protein expression, and repair the aluminum overload-induced hippocampal neuronal damage and spatial orientation impairment. It is suggested that direct intervention of 5-lipoxygenase expression has a neuroprotective role in the degeneration induced by chronic aluminum overload brain injury model.