Expression of EphB4 and HIF-1α in lung cancer and its clinical significance

作     者：Congzhong Zhu Xinyun Wang Haiyan Zheng Ting Liu Yan Li Cuiyun Sun Aixing Wang Fengyun Zhao 

作者机构：Department of Pathology Tianjin Medical University Tianjin 300070 China 

出 版 物：《The Chinese-German Journal of Clinical Oncology》 (中德临床肿瘤学杂志（英文版）)

年 卷 期：2007年第6卷第1期

页      面：9-12页

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

主　　题：肺癌 EphB4 HIF-1α 基因表达 免疫组织化学 临床意义 

摘      要：Objective: To investigate the relationship between the expression of EphB4 and HIF-1α in lung cancer and their biological significance. Methods: The expression of EphB4 and HIF-1α was detected in 54 specimens of lung cancer by using streptavidin-peroxidase (SP) immunohistochemical method, and 10 normal lung tissues as control. Results: Among the 54 cases of lung cancer, the positive rate of EphB4 was 50.0%; 42.6% of the tumors were positive for HIF-1α. The expression of these two kinds of proteins was related to gross types, differentiation and clinical stages (P0.05). A highly positive correlation was observed between the expres- sion of EphB4 and HIF-1α (P0.01). Conclusion: Overexpression of EphB4 and HIF-1α may play an important role in the pathogenesis, progression and malignant degree of lung cancer. Detection of EphB4 and HIF-1α expression might be helpful to predict prognosis of patients with lung cancer.