Reversible effect of testosterone undecanoate injection on spermatogenesis in rats

作     者：Xiao-HongWEN Wing-HaiWANG Jian-SunTONG ZHENG-WeiYANG Gui-YuanZHANG 

作者机构：MorphometricResearchLaboratoryNortltSichuanMedicalCollegeNanchong637007 JiangsuScientificandTechnologicalInstituteforFamilyPlonningNanjing210029 DepartmentofEndocrinologyNationalResearchInstituteforFamilyPlanningBeijing100081China 

出 版 物：《Asian Journal of Andrology》 (亚洲男性学杂志（英文版）)

年 卷 期：2000年第2卷第3期

页      面：207-211页

核心收录：

学科分类：1001[医学-基础医学(可授医学、理学学位)] 10[医学] 

基　　金：Financially supported by a"9th five-year" National Key Grant of Science and Technology (Grant number:969040401) and by Sichuan Committee of Education 

主　　题：spermatogenesis stereology testis testosterone undecanoate 

摘      要：Aim: To study the effect of testosterone undecanoate (TU) injection on spermatogenesis in rats. Methods:Twenty adult SD rats received vehicle or TU (8 mg/kg, 19 mg/kg or 625 mg/kg) injection, im, every 15 days for 60days, and another 38 animals received similar treatments for 130 days with half of them undergoing a recovery phase of120 days (5 rats for each treatment). At the end of the treatment, testes were removed and the diameter of the seminif-erous tubules and the number of late elongated spermatids (steps 15-19) per testis were estimated with stereologicalmethods as a measure of the spermatogenic efficiency. Results: Low dose (8 mg/kg) TU treatment virtually hadno effect on spermatogenesis. A dose of 19 mg/kg slightly suppressed spermatogenesis 60 days after treatment, and se-vere suppression occurred after another 70 days of dosing. Spermatogenesis was completely recovered at the end of therecovery phase. Large dose (625 mg/kg) TU treatment did not significantly affect spermatogenesis and was well toler-ated by animals. Conclusion: TU injection reversibly suppresses spermatogenesis in rats.