Quantification of angiogenesis by CT perfusion imaging in liver tumor of rabbit

作     者：Jiang, Hui-Jie Zhang, Zai-Ren Shen, Bao-Zhong Wan, Yong Guo, Hong Li, Jin-Ping 

作者机构：Harbin Med Coll Affiliated Hosp 4 Dept Med Imaging Harbin 150001 Peoples R China Harbin Med Coll Affiliated Hosp 2 Harbin 150086 Peoples R China 

出 版 物：《Hepatobiliary & Pancreatic Diseases International》 (国际肝胆胰疾病杂志（英文版）)

年 卷 期：2009年第8卷第2期

页      面：168-173页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：supported by grants from the Natural Science Foundation of Heilongjiang(No.D2006-07) the Heilongjiang Educational Committee(No.1511181) the National Natural Science Foundation of China(No.30370431) 

主　　题：liver neoplasms angiogenesis immunohistochemistry perfusion imaging animal model 

摘      要：BACKGROUND:Tumor angiogenesis is essential for primary and metastatic tumor *** tomography perfusion(CTP)is a new imaging method,made possible by the recent development of fast CT scanners and improved data analysis techniques,which allows measurement of the physiologic and hemodynamic properties of tissue *** study aimed to evaluate CTP in the quantification of angiogenesis and to assess the relationship between tissue perfusion parameters and microvascular density(MVD)and vascular endothelial growth factor(VEGF),attempting to detect the physiologic properties of ***:Sixteen rabbits with VX2 liver tumors underwent multi-slice CT perfusion(MSCTP)on day 14 after tumor *** parameters included hepatic blood flow(HBF),hepatic blood volume(HBV),mean transit time(MTT),permeability of capillary vessel surface(PS),hepatic artery index(HAI),hepatic artery perfusion(HAP),and hepatic portal perfusion(HPP).The border of the tumor was stained with CD34 and VEGF immunohistochemical stains,and MVD was measured by ***,CTP parameters were determined whether they were correlated with MVD and VEGF using Pearson’s correlation ***:The positive expression of MVD was different in the center and border of the tumor(P0.05).CONCLUSIONS:Significant correlations were found between perfusion parameters and MVD and ***,MSCTP can be used to evaluate tumor angiogenesis in vivo.