Intravenous proton pump inhibitors for peptic ulcer bleeding:Clinical benefits and limits
Intravenous proton pump inhibitors for peptic ulcer bleeding:Clinical benefits and limits作者机构：Institute of Clinical MedicineMedical CollegeNational Cheng Kung University Department of Internal MedicineNational Cheng Kung University
出 版 物：《World Journal of Gastrointestinal Endoscopy》 (世界胃肠内镜杂志（英文版）（电子版）)
年 卷 期：2011年第3卷第3期
页 面：49-56页
学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学]
主 题：Peptic ulcer bleeding Recurrent bleeding Comorbidity Cytochrome P-450 2C19 Proton pump inhibitor Omeprazole
摘 要：Peptic ulcer bleeding is a common disease and recurrent bleeding is an independent risk factor of *** with proton pump inhibitors(PPIs) prevents recurrent bleeding after successful endoscopic therapy.A gastric acidic environment of less than pH 5.4 alters coagulation function and activates pepsin to disaggregate platelet *** acid is secreted by H+,K+-ATPase,naming the proton *** update review focuses on the mechanism and the role of PPIs in the clinical management of patients with peptic ulcer *** intravenous omeprazole bolus followed by high-dose continuous infusion for 72 h after successful endoscopic therapy can prevent the recurrent *** the Asian,however,the infusion dosage can possibly be diminished whilst preserving favorable control of the intragastric pH and thereby still decreasing rates of recurrent *** of the infusion dosage of PPIs,rates of recurrent bleeding remain high in patients with *** recurrent peptic ulcer bleeding may be prolonged in those with co-morbidities,a lowdose infusion of IV PPIs for up to 7-day may result in better control of recurrent bleeding of peptic *** to the inter-patient variability in CYP2C19 genotypes,the infusion form of new generation PPIs,such as esomeprazole,should be promising for the prevention of recurrent *** article offers a comprehensive review of clinical practice,highlighting the indication,the optimal dosage,the duration,and the potential limitation of PPIs infusion for peptic ulcer bleeding.
维普期刊数据库