Animal models of Huntington's disease: implications in uncovering pathogenic mechanisms and developing therapies
Animal models of Huntington’s disease: implications in uncovering pathogenic mechanisms and developing therapies作者机构：Department of Physiology Soochow University School of Medicine Suzhou China Department of Pharmacology Soochow University School of Medicine Suzhou China
出 版 物：《Acta Pharmacologica Sinica》 (中国药理学报(英文版))
年 卷 期：2006年第27卷第10期
页 面：1287-1302页
核心收录：
学科分类：1007[医学-药学(可授医学、理学学位)] 1002[医学-临床医学] 100204[医学-神经病学] 10[医学]
基 金：Project supported by the National Natural Science Foundation of China(No 30370506) by the Specialized Research Fund for the Doctoral Program of Higher Education(No 20050285017)
主 题：Huntington’s disease huntingtin neurodegeneration animal models
摘 要：Huntington’s disease (HD) is an autosomal dominant neurodegenerative disorder,which is caused by an abnormal expansion of Cytosine Adenine Guanine (CAG)trinucleotide repeat in the gene making huntingtin (Htt).Despite intensiveresearch efforts devoted to investigate molecular mechanisms of pathogenesis,effective therapy for this devastating disease is still not available at *** of various animal models of HD has offered alternative approachesin the study of HD molecular *** HD models,including chemical-induced models and genetic models,mimic some aspects of HD symptoms *** date,however,there is no ideal model which replicates all of theessential features of neuropathology and progressive motor and cognitive impair-ments of human *** a result,our understanding of molecular mechanisms ofpathogenesis in HD is still limited.A new model is needed in order to uncover thepathogenesis and to develop novel therapies for *** this review we discussedusefulness and limitations of various animal and cellular models of HD in uncov-ering molecular mechanisms of pathogenesis and developing novel therapies forHD.
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