Immunomodulatory effects and mechanisms of plant alkaloid tetrandrine in autoimmune diseases

作     者：LAI Jenn-HaungRheumatology/Immunology and Allergy, Department of Medicine, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan, China 

作者机构：Rheumatology/Immunology and Allergy Department of Medicine Tri-Service General Hospital National Defense Medical Center Taipei Taiwan China 

出 版 物：《Acta Pharmacologica Sinica》 (中国药理学报(英文版))

年 卷 期：2002年第23卷第12期

页      面：40-48页

核心收录：

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

基　　金：Project supported by National Health Research Institutes Taiwan China.(NHRI-GT-EX89B915C)and Tri-Service General Hospital(TSGH-C91-13) 

主　　题：tetrandrine T-lymphocytes autoimmune diseases alkaloids 

摘      要：Autoimmune diseases characterized by activation of immune effector cells and damage of target organs are currently treated with a combination of several disease-modifying antirheumatic drugs (DMARDs) that preserve different immunomodulatory mechanisms. Such a combination treatment strategy not only provides synergistic effects but also reduces side effects from individual drug. Tetrandrine (Tet), purified from a creeper Stephania tetrandra S Moore, is a bis-benzylisoquinoline alkaloid and has been used to treat patients with silicosis, autoim-mune disorders, and hypertension in China’s mainland for decades. The accumulated studies both in vitro and in vivo reveal that Tet preserves a wide variety of immunosuppressive effects. Importantly, the Tet-mediated immu-nosuppressive mechanisms are evidently different from some known DMARDs. The synergistic effects have also been demonstrated between Tet and other DMARDs like FK506 and cyclosporin. These results highlight Tet a very potential candidate to be consid