Tuning of neocortical astrogenesis rates by Emx2 in neural stem cells

作     者：Carmen Falcone Antonello Mallamaci 

作者机构：Laboratory of Cerebral Cortex DevelopmentSISSATriest I-36134Italy 

出 版 物：《Neural Regeneration Research》 (中国神经再生研究（英文版）)

年 卷 期：2015年第10卷第4期

页      面：550-551页

核心收录：

学科分类：1001[医学-基础医学(可授医学、理学学位)] 100101[医学-人体解剖与组织胚胎学] 10[医学] 

基　　金：fully supported by SISSA in tramurary funding 

主　　题：Tuning of neocortical astrogenesis rates by Emx2 in neural stem cells NSCs Figure GOF stem 

摘      要：Generation of astrocytes within the murine developing cerebral cortex mainly takes place during the first postnatal week, after neuronogenesis and prior to the bulk of oligogenesis. This process involves a great variety of highly complex regulatory mechanisms. Astrocytic outputs depend on two primary factors： progressive commitment of multipotent precursors to astroglial fates and proper tuning of proliferation of astrocyte-committed progenitors. To date, several regulatory mechanisms have been identified for the former process, while very little is known about modulation of astroblast proliferation （reviewed in Mallamaci,